Acromegaly You may look at that person up above and think one of two things: 1. “Whoa, he’s huge.” 2. “Meh, other wrestlers are better.” Either way you take it, the Great Khali (pictured above), a fairly well known wrestler, is only … Continue reading Acromegaly
This topic covers the Inclusion Bodies within Red Blood Cells. Combined with Morphological Abnormalities of Red Blood Cells, we now know everything there is that can go wrong with one red blood cell. Continue reading Inclusion Bodies of Red Blood Cells
This topic covers all the morphological abnormalities that a red blood cell can undergo. It includes detail of the morphological abnormality, diseases that cause it, and tips to identify it. Continue reading Morphological Abnormalities of Red Blood Cells
This topic is a brief introduction to the world of Hematology by discussing General Features of Anemia. This is meant only to allow the reader to have a sound understanding of a foundation of anemia, its symptoms, signs and clinical importance in a general format. Continue reading General Characteristics of Anemia
This topic is the second part of Bacterial Taxonomy. We classify bacteria into obligate aerobes, facultative anaerobes, microaerophilic organisms and obligate anaerobes. Continue reading Bacterial Taxonomy 2 – Classification of Bacteria Based on Metabolic Characteristics
This topic is another introductory topic in Microbiology. The aim is to understand the gram stain, and then by extension, what bacteria are gram positive, and what bacteria are gram negative. Emphasis will also be given to taxonomy based on morphology – namely, cocci, baccili, spirilla or pleomorphic. Continue reading Bacterial Taxonomy 1 – Classification Based on Morphology and the Gram Stain
This topic covers the concept of Calcification. In this, I cover both well known types of calcification, including dystrophic and metastatic calcifications, and also talk about calcium related pathologies such as Gamma-Gandy Bodies, Psammoma Bodies, Hypercalcemia, and Calcification related conditions such as Calcific Aortic Stenosis, Heterotrophic Ossification, Calcinosis Cutis, Monckeberg’s arteriosclerosis among others. Hope you guys enjoy! Continue reading Calcification
This topic covers the mechanism of irreversible cell injury. We talk about each mechanism in which cells can be irreversibly damaged, including ATP depletion, Mitochondrial Damage, Influx of Ca2+ and disruption of Ca2+ homeostasis, Reactive Oxygen Species, Membrane Damage, DNA and Protein Damage. Continue reading Mechanism of Irreversible Cell Injury
Cellular Adaption To Stress
Cellular adaptation refer to (usually) reversible changes in size, number, phenotype or appearance, metabolic activity or functions of cells in response to adverse environmental conditions or internal bodily stresses.
Basically, just as we react to something in our environment, cells don’t just sit there and take their punishment – they change to try to conquer the problem.
There are 4 important ways in which they do this:
Hypertrophy and Hyperplasia
Hypertrophy is a cellular response that involves the increased size of cells, that results in an increase in size of the affected organ.
Note that there is no increase in the number of cells, rather JUST the size. This type of cellular adaptation to stress occurs in a number of different cells, and is usually coupled with another type of cellular adaptation, hyperplasia.
Hyperplasia is a cellular response that involves the increase in number of cells in response to a stimulus.
Both hyperplasia and hypertrophy occur as compensatory mechanisms to an increased workload on the organ or cell.
To remember which is which, think of the prefix and suffix that make up the word. The suffix “plasia” means “development” and thus hyperplasia means “increased development,” corresponding to an increase in the number of cells. Similarly, “-trophy” means “sustenance, nutrition” and thus, hypertrophy refers, in fact to the very mechanism of hypertrophy, an increase in factors that sustain and allow growth of the cells, which will be explained later.
If cells are divided into cells that are capable of dividing, and cells that are incapable of dividing, we can also divide the way they react to increased stress.
- Cells capable of dividing respond to an increased workload using both hyperplasia and hypertrophy.
- Cells incapable of dividing can only respond to an increased workload by hypertrophy. An example of this is in myocytes, or cardiac muscle cells in myocardial fibres. Thus, the heart mainly responds to an increased workload by hypertrophy. Other examples are adult skeletal muscles and neurons.
Physiologic vs Pathologic Hypertrophy and Hyperplasia:
Hypertrophy and hyperplasia, while it can be physiological to aid the body, may also be disease related, or pathological, and is a very important indicator of disease.
Physiologic Hypertrophy: is caused by an increased workload, increased functional demand or stimulation by hormones and growth factors. Of these, the most common stimulus for hypertrophy is increased workload. An example of workload induced hypertrophy would be the muscle enlargement in bodybuilders as muscles are forced to tolerate new loads. An example of hormone-induced hypertrophy is within the endometrium and myometrium of the uterus, as estrogen upregulation during the follicular stage of the menstrual cycle stimulates an increase in muscle proteins in the stroma of the endometrium and the large smooth muscle layer of the myometrium, and thus, muscle size.